Simply apply two drops of Clean Teeth Gel to each side of your dog’s mouth. After application, you’ll notice your pet licking their lips repeatedly; this is normal and helps the gel coat the teeth and gums. For maximum effect, withhold food and water for 30 minutes before and after application. While toothbrushing is not required, it can speed up the removal of plaque and tartar when used with the gel. Apply once daily in the evening.